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Volume 79, Issue 6
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III. The Study of Immunocompetence of Tissue Infiltrating Lymphocytes in Bladder TumorsHironori Tsujihashi1988 Volume 79 Issue 6 Pages 977-984
Published: June 20, 1988
Released on J-STAGE: July 23, 2010
JOURNAL FREE ACCESSTissue infiltrating lymphocytes (TIL) in bladder tumors are supposed to be an expression of the host resistance against bladder tumor in local sites. We investigated the functional activity of TIL in comparison with peripheral blood lymphocytes (PBL). Isolation of TIL was performed via enzyme cocktail treatment by Ficoll-Hypaque discontinuous gradient centrifugation.
Measurement of lymphocyte subsets by flow cytometry demonstrated that 43.6% (Leu4; T cells), 10.5% (Leu10; B cells) and 13.1% (Leu7; NK cells) were found in TIL. TIL in vitro incubation with IL2 for 4 days showed a killing activity against autologous tumor cells by trypan blue dye exclusion test. IL2 induced increases in cytotoxic T and activated NK cells in their phenotype.
Concomitantly, the cytotoxic activity of TIL and PBL were tested in a 4 hour 51Cr-release assay. Myeloid K562 cells (NK sensitive), HT1197 (bladder tumor) and fresh bladder tumors were used as target cells. The spontaneous NK cell activity of PBL was 23.7%, whereas that of TIL was very low. However, in vitro IL2 cultivation with lymphocytes induced a remarkable augmentation of NK activity in TIL as well as in PBL. On the other hand, the spontaneous LAK activity of PBL and TIL was very low. IL2 cultured-PBL and-TIL exhibited the highest levels of lysis against fresh bladder tumors. The cytotoxicity of TIL against autologous bladder tumors induced by IL2 unlike PBL was higher than that against allogenic bladder tumors.
Furthermore, immunomodulators (OK432, IL2) were injected intratumorally by the endoscopic technique. Measurements of lymphocyte subsets in TIL resulted in an increase of T and NK cells following immunomodulators injection. Endoscopic injection of immunomodulators into bladder tumors augmented NK cell functional activity in TIL as well as PBL.
These findings suggest that local immunosurveillance plays a role against bladder tumor. Further studies are required to elucidate host immune response in the microenvironment of the cance site, as well as the systemic immune reaction.View full abstractDownload PDF (2499K) -
Akio Fujii, Shinichi Morishita, Ichiro Nakamura, Yasuhiko Oka, Hideo O ...1988 Volume 79 Issue 6 Pages 985-993
Published: June 20, 1988
Released on J-STAGE: July 23, 2010
JOURNAL FREE ACCESSFourteen patients selected for this study were treated with MVP-CAB between May 1985 and August 1987. All 14 patients with metastatic urothelial tract cancer had evaluable and measurable lesions. Chemotherapy was given in 3-to 4-week cycles as follows; On day 1, 20mg/m2 MTX, 0.6mg/m2 VCR, 500mg/m2 CPM, 20mg/m2 ADM, and 30mg/body BLM, were administered by drip infusion over about 2 hours. On day 2, 50mg/m2 CDDP was administered with hydration over about 1 to 2 hours. A total of 65 cycles were administered in the 14 patients. The median number of treatments per patient was 4.6 cycles (range 1 to 13). PR was achieved in 11 of 14 patients, with an overally response rate of 79%. The duration of survival in responders ranged from 3 to 26 months (median, 11.5 months) and in nonresponders, 2 to 9 months (median, 6.3 moths). There was a significant difference in the duration of survival by Kaplan-Meier between the two groups (p<0.01). The main toxic effect was leukopenia. Although leuopenia (WBC<4000/mm3) was noted in 13 patients (93%), 9 (64%) of them had a WBC count nadir below 2000/mm3. Severe infection, such as sepsis, could be prevented.View full abstractDownload PDF (4969K) -
Makoto Fujisawa, Mitsuru Morikawa, Masato Sasaki, Masanobu Miyata, Shi ...1988 Volume 79 Issue 6 Pages 994-1001
Published: June 20, 1988
Released on J-STAGE: July 23, 2010
JOURNAL FREE ACCESSThe endourological techniques for upper urinary tract diseases have developed mainly for the endoscopic treatment of upper urinary tract stones. Only a few studies on endoscopic incision of ureteropelvic junction obstruction (endopyelotomy) has been reported up to now.
We incised primary ureteropelvic junction obstruction in 8 cases, with a rigid cutting instrument, percutaneously, by full thickness incision. There were 7 successful cases out of 8 (87.5%). No complication was seen in all cases. The longest follow-up is 13 months.
Since endopyelotomy does not disturb the ureteral blood supply, and the post-operative morbidity is much less than the conventional surgery, it seems to be a useful method for the treatment of ureteropelvic junction stenosis.
Because long-term results are not available, careful follow-up of the patients should be necessary.View full abstractDownload PDF (7884K) -
Akio Maki1988 Volume 79 Issue 6 Pages 1002-1010
Published: June 20, 1988
Released on J-STAGE: July 23, 2010
JOURNAL FREE ACCESSHyperprolactinemia is known to decrease sexual libido or cause oligozoospermia, etc. It has been reported that sexual ability by the central mechanism is inhibited by serotonin (5-hydroxytryptamine, 5HT) and stimulated by dopamine (DA), and that secretion of prolactin (PRL) is accelerated by 5HT and that of PRL is inhibited by DA.
Thus, we determined serum PRL, FSH, LH and testosterone (T) in 955 patients with sexual dysfunction in an attempt to clarify the association of sexual dysfunction with PRL, and obtained the following results from 105 out of these patietns, whose serum DA and 5HT levels were also measured.
1. Hyperprolactinemia was found to have developed in 85 (8.9%) of the 955 patients.
2. Serum FSH, LH and T levels were all higher than normal levels in patients with hyperprolactinemia (exceeding 50nglml).
3. The serum DA level in the impotence group was significantly lower than that in the control group.
4. The serum 5HT level in the impotence group was significantly higher than that in the control group.
5. Although the serum DA level in the hyperprolactinemia group was significantly lower than that in the control group, no appreciable difference was noted between the two groups'5HT level.View full abstractDownload PDF (1083K) -
Clinical Experience on 198 Cases in Tohoku UniversityKoichi Kambe, Masaaki Kuwahara, Shizuichi Kageyama, [in Japanese], Nao ...1988 Volume 79 Issue 6 Pages 1011-1018
Published: June 20, 1988
Released on J-STAGE: July 23, 2010
JOURNAL FREE ACCESSWe have developed an original extracorporeal lithotriptor of which energy source is underwater microexplosion (Microexplosive Extracorporeal Shock Wave Lithotripsy: mESWL). Since March, 1985, we applied this system to more than 220 clinical cases. This report shows the result of the first 198 cases which were followed up more than six months. Among the 198 cases, 30 cases were treated for residual stones of percutaneous lithotripsy. The clinical success rate of the mESWL monotherapy on 168 cases was 91% (153 cases) including 128 cases of stone-free and 25 cases with small residual fragments smaller than 4mm in major diameter. After mESWL monotherapy, 15 cases (9%) had large residual stone(s) (more than 5mm in major diameter), so they were judged as failed cases in this report. Average number of the shots of explosion per patient was 248 and average number of the sessions was 1.4. Major complications were not experienced except in 4 cases; one case of gastrointestinal bleeding, one case of bacteremia and two cases of renal subcapsular hematoma. The treatments were generally performed without anesthesia.View full abstractDownload PDF (3757K) -
Takanori Masaki1988 Volume 79 Issue 6 Pages 1019-1024
Published: June 20, 1988
Released on J-STAGE: July 23, 2010
JOURNAL FREE ACCESSThe following experiment was performed to estimate the kinetics of renal pelvic creatinine in chronic unilateral and completely obstructed kidney and values of creatinine clearance.
Hydronephrosis was prepared in 20 mongrel dogs up to 5-40 days in a period during when a unilateral ureter was obstructed by complete ligature and the renal pelvic urine was replaced with physiological saline to measure the change in renal pelvic creatinine with time. Further, creatinine clearance was estimated from renal pelvic capacity and serum creatinine concentration.
Creatinine was excreted into the renal pelvis even in the completely obstructed kidney.
Values of creatinine clearance were 0.36±0.09, 0.19±0.08, 0.09±0.05 and 0.09±0.05 and 0.09±0.05ml/min/10kg body weight (mean S. D., n=5) in 5, 10, 20 and 40 days, respectively, during the period of obstruction.
The amount of hydronephrotic creatinine in 40 days during the period of obstruction was less than the estimated creatinine amount, suggesting that the creatinine once excreted was obsorbed again in the chronic completely obstructed kidney.
This experimental method was considered adequate for estimating the renal function in chronic complete obstruction of the ureter.View full abstractDownload PDF (751K) -
Yoshio Aso, Atsushi Tajima, Kazuo Suzuki, Yoshihisa Ohtawara, Yoshio O ...1988 Volume 79 Issue 6 Pages 1025-1031
Published: June 20, 1988
Released on J-STAGE: July 23, 2010
JOURNAL FREE ACCESSThe Department of Urology, Hamamatsu University School of Medicine was opened in April, 1977. And our clinic in University Hospital started in November of the same year. Out-patients and in-patients at our clinic during the past 10 years from the opening to March, 1987 were statistically analysed in this report.
The number of patients on the first visit to the out-patient clinic during the period of 10 years totaled 10, 245. The order of incidence of diseases in the patients on the first visit to the out-patient clinic is as follows; non-specific infection (25.6%), obstructive uropathy (11.1%), urinary stone (11.1%), anomaly (7.3%), microscopic hematuria (5.3%), malignant neoplasia (3.8%), neurogenic bladder (3.1%), renal failure (2.5%), enuresis (2.2%), male infertility (2.1%), hydrocele (1.0%), movable kidney (1.0%), proteinuria (1.0%), parathyroid or adrenal tumor (0.7%), trauma (0.7%), renal cyst (0.6%), urogenital tuberculosis (0.3%) and others (20.6%).
On the other hand, the number of in-patients during the period of 10 years totaled 2, 064; the number of beds being 30. The incidences of various diseases were as follows; malignant neoplasia (23.9%), urinary stone (17.9%), obstructive uropathy (14.5%), renal failure (10.6%), anomaly (9.7%), parathyroid or adrenal tumor (4.7%), nonspecific infection (3.9%), kidney donor (2.8%), renal cyst (1.3%), neurogenic bladder (0.9%), male infertility (0.8%), hydrocele (0.6%) and other (8.4%).
The high proportion of patients with renal failure related to renal transplanation and patients with parathyroid or adrenal tumor may be said to be the characteristics of our clinic.View full abstractDownload PDF (724K) -
Hisashi Nakamura1988 Volume 79 Issue 6 Pages 1032-1039
Published: June 20, 1988
Released on J-STAGE: July 23, 2010
JOURNAL FREE ACCESSThe transition of the bladder and urethral function was examined after suprasacral spinal cord transection was made.
Twenty cats were studied. Their spinal cords were transected at T10 level and simultaneous recordings of the bladder pressure and external sphincter electromyography were performed weekly for 4 weeks.
The external sphincter electromyographic activity was observed immediately after spinal cord transection. Thus, it seems that periurethral striated muscles have a unique character that differs from skeletal muscles.
All cats which had restored bladder contractility had shown detrusorsphincter-dyssynergia within 3 weeks after transection.
But 2 out of the 8 cats showed synergia at the end of 4-week recording while the micturitional ability of the 2 cats was deteriorated and considerable amount of residual urine was present. Therefore, it was supposed that the normal micturition necessitated the upper micturitional centers in the pons and cerebrum.
One of the 4 cats which showed inactive bladder-hyperactive sphincter type developed a hyperactive bladder-hyperactive sphincter type. Therefore, it is possible that inactive bladder-hyperactive sphincter type is one of the processes before restoring bladder contractility.
Four weeks after the transection, 4 types of bladder and urethral functions appeared.
They are hyperactive bladder-hyperactive sphincter type, hyperactive bladder-urethral relaxation type, inactive bladder-hyperactive sphincter type, and inactive bladder-inactive sphincter type.
The present study indicated that the sacral micturitional center which was separated from the upper ones went through the individually different processes and gained its own micturitional automaticity.View full abstractDownload PDF (3058K) -
Hiroyuki Kaneto, Tamihiko Chiba, Tohru Takahashi, Seiichi Orikasa1988 Volume 79 Issue 6 Pages 1040-1048
Published: June 20, 1988
Released on J-STAGE: July 23, 2010
JOURNAL FREE ACCESSUreteral walls from twelve autopsy cases of various ages were submitted to stereomorphometric studies on the architecture of mural smooth muscles at the ureteropelvic junction. Serial histological sections in parallel with the wall were prepared from the specimens that were extended on a flat board, fixed in formalin and embedded in celloidin-paraffin. Computer-aided 3D reconstruction from these sections disclosed the basic muscular architecture to be a network comprizing variously oriented bundles. In a geometric model simplifying each bundle into a vector of corresponding size and direction, the pattern of architecture was described in the form of vector distribution with respect to their angle against the cross-sectional plane. It was disclosed that in the neonates, a circular arrangement of muscles prevails, whereas the pattern is transformed into an oblique mesh structure after seven years due to a gradual increase of longitudinal elements, a change reflected in the vector distribution as a shift from a monomodal (circular) toward a bimodal pattern. Responsible for this age-dependece was a process of unfolding of a preformed mesh structure with the growth and elongation of the ureter. From a physiological viewpoint, the mesh structure appeared indispensable in producing and transmitting urinary boluses. On the other hand, there were fine longitudinal muscles emerging at two years beneath the mucosal layer; these, not having any connections with the mesh-forming outerlayer, were considered an auxiliary minor part of the ureteral musculature.View full abstractDownload PDF (5090K) -
Takumi Yamada, Iwao Fukui, Masayuki Yokogawa, Hiroyuki Oshima1988 Volume 79 Issue 6 Pages 1049-1053
Published: June 20, 1988
Released on J-STAGE: July 23, 2010
JOURNAL FREE ACCESSMalignant progression (deeply invasive or metastatic carcinoma) developed subsequently to bladder-reserving therapy in 38 of 515 patients who had initially noninvasive and superficially invasive papillary transitional cell carcinoma of the bladder (Ta and T1). A retrospective study was performed concerning the interval and number of recurrence from initial tumor to malignant progression, and expression of ABH blood group, T and cryptic T antigens of initial tumors. In 3 patients with initially grade 1 tumors, intervals were 8, 13 and 14 years and their tumor recurrence was over 10 times in 2 of these patients prior to malignant progression. In 21 patients with initially grade 2 tumors, 11 developed malignant progression within 3 years, 8 from 4 to 6 years and 2 over 10 years later. Tumor recurrnce was less than 3 times in 12 patients and more than 4 times in 9 patients. In 11 patients with initially grade 3 tumor, 9 progressed within 3 years and recurrence prior to malignant progression was less than 2 in 7 patients. Stains of ABH blood group, T and cryptic T antigens in tumor tissues was done in 16, 12 and 12 patients, respectively. ABH-antgens in initial tumors were negative in only 2 of the 16 cases and T and cryptic T antigens in the tumor were, respectively, negative and positive in all cases examined. In conclusion, presence or deletion of ABH blood group, T and cryptic T antigens in initial tumors appears not applicable to prediction of subsequent malignant progression of initially noninvasive and superficially invasive papillary transitional cell carcinomas of the bladder.View full abstractDownload PDF (631K) -
Akihiko Takamizawa1988 Volume 79 Issue 6 Pages 1054-1062
Published: June 20, 1988
Released on J-STAGE: July 23, 2010
JOURNAL FREE ACCESSUsing nuclear morphometry, the author tried to objectify histological grading by nuclear atypia of renal cell carcinoma, and simultaneously examined its relationship with nuclear DNA ploidy. The subjects were 35 preoperatively untreated cases of renal cell carcinoma. The region of the highest histological grade was selected from H-E stained specimen, manually measured for 300 nuclei under 1, 000 times of oil immersion by means of graphic digitizer, and measured for mean nuclear area and correct nuclear roundness factor (NRF). From the paraffin-embedded tissue just below the measured area, nuclear DNA ploidy pattern was analyzed by cytofluorometry.
The relation of histological grading with mean nuclear area and correct NRF was: 30.8±7.7μm2 and 32.0±10.1 for 12 cases of the group grade 1, 36.4±5.6 μm2 and 37.7±12.8 for 16 cases of the group grade 2 and 48.3±9.8μm2 and 71.1±24.1 (mean±SD) for 7 cases of the group grade 3.The both parameters showed significant differences between the group grade 3 and the group grade 1 or the group grade 2. As for the prognosis, cancer death was frequent for the group of mean nuclear area≥37.3μm2 or the group of correct NRF≥45.7; an obvious significant difference (p<0.01) in the survival curves was seen between their respective low-value groups, indicating that prognosis could be made more correctly than histological grading. Incidence of abnormal nuclear DNA ploidy pattern increased with a rise of histological grade, and both mean nuclear area and correct NRF showed similar behaviors.
In the examination of histopathological specimens of renal cell carcinoma, the measurement of mean nuclear area and correct NRF was regarded as providing with an objective index of histological grading corresponding to biological malignancy.View full abstractDownload PDF (1112K) -
Shinichiro Torii, Toyohei Machida, Yukihiko Ohoishi, Yukio Tateno, Nob ...1988 Volume 79 Issue 6 Pages 1063-1069
Published: June 20, 1988
Released on J-STAGE: July 23, 2010
JOURNAL FREE ACCESSThe mathematical study of dynamic renal function and the simulation of renal disorder in rabbit kidney using MRI by Gd-DTPA were performed. T1 of rabbit kidney, which had been operated (complete unilateral ureteral occulusion or incomplete unilateral occlusion of renal artery) was calculated before and after intravenous injection of 0.05mmol/kg Gd-DTPA, continuously for 90 minutes. All images were obtained by the 0.1 Tesla resistive type MRI. The changes of 1/T1 of cortex and medulla of both kidneys were calculated (MRI renogram).
The 4 compartment model of bilateral kidneys was established by 6 normal MRI renogram and renal blood flow-glommelurar function parameter and tubural excration function parameter were calculated by the Runge-Kutta-Gill method and the nonlinear least squares method (Simplex method).
The change of renogram pattern was observed by the mathematical change of such parameters and comparative study was performed between such mathematical simulation and practical cases. The actual change of such parameters were calculated by the experimental model of rabbit kidney.
It was concluded that the change of MRI renogram pattern was sensitive for unilateral hydronephrosis, renal parenchymal dysfunction by obstructive uropathy and unilateral renal arterial stenosis. Quantitative observation of focal renal parenchymal dysfunction, which was induced by ureteral obstruciton, was possible. In the near future it will be also possible to detect acculate ERBF and GFR by the mesurement of T1 of human kidney.View full abstractDownload PDF (919K) -
Tomoyoshi Terakawa, Jiro Kuroda, Masayasu Tokizane, Shinya Nishizaki, ...1988 Volume 79 Issue 6 Pages 1070-1077
Published: June 20, 1988
Released on J-STAGE: July 23, 2010
JOURNAL FREE ACCESSEndourethral submucosal teflon injection was performed in 8 patients with urinary incontinence. Of them three after TURP, three with spina bifida, one after vertebral operation and one after urethroplasty for epispadias. Four patients have achieved continence after one or two sessions. Complications were minimal. The results including complications of this technique after long term follow-up were reviewed in the literatures and discussed.View full abstractDownload PDF (5613K) -
Yoshitsugu Nasu, Daisuke Yamada, Masatoshi Noda, Masaya Tsugawa, Mikio ...1988 Volume 79 Issue 6 Pages 1078-1084
Published: June 20, 1988
Released on J-STAGE: July 23, 2010
JOURNAL FREE ACCESSSerum and urinary α1-microglobulin (AMG) levels were studied in 494 patietns with urological diseases and were compared with other parameters of the renal funciton, mainly with β2-microglobulin (BMG) levels.
1) Serum AMG levels had good correlation with other parameters including Ccr, BUN, serum creatinine and PSP test. Serum BMG levels, however, had better correlation with other renal parameters than serum AMG.
2) In urological field, serum AMG levels in patients with malignancy, especially with renal cell cancer, tended to elavate. Therefore simultaneous measurement of serum AMG and BMG levels is not so meaningful for the evaluation of renal function in patients with urological malignancy.
3) In general, the renal function is gradually impaired by ageing. However, serum AMG levels did not elevate with age.
4) There were no correlations among three urinary levels of AMG, BMG and N-acetyl-β-glucosaminidase (NAG).View full abstractDownload PDF (787K) -
Tadaichi Kitamura, Nobuo Moriyama, Kazuki Kawabe, Yoshio Aso1988 Volume 79 Issue 6 Pages 1085-1089
Published: June 20, 1988
Released on J-STAGE: July 23, 2010
JOURNAL FREE ACCESSOne gram oral calcium tolerance test was performed on 116 calcium-containing urinary stone formers (SF), 8 patients with primary hyperparathyroidism (PHPT) and 10 normal controls (Normal). According to the criteria modified from Pak et al., the 116 SF were classified into 3 groups of 82 patients with normocalciuric nephrolithiasis (NN), 13 with absorptive hypercalciuria (AH) and 21 with renal hypercalciuria (RH). Adding these 3 groups to the groups PHPT and Normal, 5 groups were subjected to the evaluation in this study.
Changes in urinary P/Cr ratio before and during oral calcium tolerance test were examined in the 5 groups. Mean urinary P/Cr ratio in group PHPT increased significantly, whereas that in the remaining 4 groups demonstrated a significant decrease (group RH) or no significant change (groups AH, NN and Normal). In addition, the mean urinary P/Cr ratio was maintained high throughout oral calcium tolerance test in group PHPT, as compared to the ratios in the other 4 groups.
In summary, urinary P/Cr ratio in group PHPT was increased continuously during oral calcium tolerance test, as observed in rapid calcium infusion test by Goldsmith et al., suggesting that change in urinary P/Cr ratio may be used as one of the parameters for diagnosing PHPT. However, since there are a certain number of false positive cases, it may not be wise to diagnose PHPT by change in urinary P/Cr ratio alone.View full abstractDownload PDF (515K) -
Yasuo Fukushi, Seiichi Saito, Seiichi Orikasa, Haruo Ohtani1988 Volume 79 Issue 6 Pages 1090-1095
Published: June 20, 1988
Released on J-STAGE: July 23, 2010
JOURNAL FREE ACCESSImmunohistochemical observation of human renal cell carcinoma tissue using monoclonal antibodies FH4 and FH6, directed to dif ucosyl Lex and sialosyl dif ucosyl Lex structure, respectively, was performed. According to the staining pattern, tisse samples of 50 cases of renal cell carcinoma were devided into the following three groups; Group A (FH4 positive, FH6 positive), Group B (FH4 positive, FH6 negative), and Group C (FH4 negative, FH6 negative). This immunohistochemical grouping correlates to histological grading, but not to clinical staging. Although histological grading did not correlate to prognosis of the patient's postoperative course, Breslow's examination revealed that the cases included in group A showd a significantly favourable postoperative course compared to the cases of the other groups (p<0.001).
These results indicate that expression pattern of these oncofetal antigens is a good parameter indicating the degree of tumor cell differentiation and malignancy, and reflects the prognosis of the patients.View full abstractDownload PDF (2520K) -
Yoshio Aso, Hiroaki Masuda, Jun Hirose, Souichi Mugiya, Masaaki Maruya ...1988 Volume 79 Issue 6 Pages 1096-1102
Published: June 20, 1988
Released on J-STAGE: July 23, 2010
JOURNAL FREE ACCESSThe present study reports the results of treatment in 67 cases of renal cell carcinoma during the 10 years from 1977 to 1987. Overall 1, 3 and 5-year survival rates by Kaplan-Meier method were 79.8, 64.1 and 55.5 percents, respectively.
Several factors which might be related to prognosis were analysed. As a result, anemia, increased erythrocyte sedimentation rate, postive C-reactive protein, decreased serum albumin, elevated serum α1-globlin and mixed echo pattern were found to be poor prognostic factors. By pathological study, the stage and the histological grade of tumors were found to be significant prognostic factors, while the importance of cell type, structual pattern and microinfiltration as a prognostic factor was not clearly demonstrated.
The cases with renal cell carcinoma were treated with the combined adjuvant therapy of chemotherapy (FT 207, 5-FU or UFT) and nonspecific immunotherapy (OK-432: Picibanil) postoperatively. It appeared that the postoperative adjuvant therapy was useful for the improvement of prognosis.View full abstractDownload PDF (881K) -
So Nakamura, Ken Marumo, Taro Shibayama, Shiro Baba, Nobuhiro Deguchi, ...1988 Volume 79 Issue 6 Pages 1103-1107
Published: June 20, 1988
Released on J-STAGE: July 23, 2010
JOURNAL FREE ACCESSA case of renal cell carcinoma with multiple pulmonary metastases achieved a complete response after a sequential combination therapy with interferon-γ(IFN-γ) and OK-432.
A 54-year-old male (K. M. #60528) was found to have multiple pulmonary coin lesions on chest X-ray films 6 months after radical nephrectomy for renal cell carcinoma of the right kidney. Aspiration needle biopsy confirmed the diagnosis of pulmonary metastases. Daily administration of IFN-γ at a dose of 9 million units was continued for 6 weeks, resulting in a progression of the disease, OK-432 was chosen as an adjuvant immunotherapy. After 12 weeks, the subjective symptoms improved and the pulmonary coin lesions became contracted, and the evaluation was a partial response. After 13 months with OK-432, the coin lesions disappeared completely, and the final evaluation was a complete response.
There is no report that single administration of OK-432 resulted in a complete response of renal cell carcinoma. Our speculation on the mechanism is that the sequential treatment with IFN-γ and OK-432 enhanced an immune response in host tumor relation as biological response modifiers.View full abstractDownload PDF (3341K) -
Toshihiko Kobari, Toyohei Machida, Akihiko Ohishi, Shigeyuki Kotera, T ...1988 Volume 79 Issue 6 Pages 1108-1113
Published: June 20, 1988
Released on J-STAGE: July 23, 2010
JOURNAL FREE ACCESSThe author has recently experienced a very rare case of Bellinis duct carcinoma originated from distal ductules and the following report describes the diagnosis, treatment and clinical development. The patient was a male of 63 in age who presented at the hospital with the chief complaint of visible hematuria and pain in the right abdomen.
Renal cellular carcinoma was suspected by image diagnosis and operation was performed. Since it was found to be a highly differentiated mamillaly-shaped adenocarcinoma, a primary tumor of the lower nephron was suspected and further tissues tinction tests using 4 types of biotinized lectin and 4 types of monoclonal antibodies were made. With the results of soybean aggutinin (++) peant agglutinin (+), Dolichos biflorus agglutinin (+), Lotus tetragonolobus agglutinin (+), Tamm-Horsfall protein (-), Cytokeratin (+), Epithelial membrane antigen (++), and Vimentin (-), it was ultimately diagnosed as a Bellinis duct carcinoma. The patient was treated by chemical radiation and thermal theraphy. However, due to drastic development after 9 months, the patient died from the carcinoma.View full abstractDownload PDF (6440K) -
A Case of Stage IIB, Non-Seminomatous Testicular TumorToyoaki Uchida, Tatsuo Kawakami, Mikitoshi Go, Masanori Sawamura, Hiro ...1988 Volume 79 Issue 6 Pages 1114-1118
Published: June 20, 1988
Released on J-STAGE: July 23, 2010
JOURNAL FREE ACCESSA twenty-three-year-old male, who had undergone left orchiectomy due to mature teratoma associated with embryonal cell carcinoma and choriocarcinoma about one month before, was referred to us for further treatment.
An attempt of retroperitoneal lymphonode dissection immediately after the admission was unsuccessful because of extensive tumor invasion.
The results of two courses of chemotherapy with BVP regimen were fairly satisfactory and α-fetoprotein dropped to normal range. Eight months later, another course of chemotherapy with Etoposide, Vincristine, Peplomysin and CDDP was done for recurrent retroperitoneal lymphnode swelling and elevated α-fetoprotein but with partial response.
Three months later, the patient underwent retroperitoneal lymphnode dissection and simultaneous left nephrectomy because of extensive invasion of metastatic tumor involving the renal pedicle. The patient developed acute renal failure immediately after the operation and underwent chronic hemodialysis. Thirty-one months later, the patient successfully dispensed with hemodialysis with recovery from impaired renal function.
The patient has been in good condition without any evidence of tumor recurrence up to the present, about 14 months after cessation of hemodialysis treatment.View full abstractDownload PDF (2742K)
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