Trans-omics: A Novel Approach for Proteomics Data Analysis

Abstract

Recent advances in omics analysis have facilitated quantitative measurement for various molecular activity in vivo beyond large scale quantification. However, there is no guideline for how to analyze these types of omics data properly and, in general, scientists have to struggle with acquired omics data to find a clue for a novel biological findings. To overcome this challenge, we propose “trans-omics” analysis for reconstructing molecular networks by connecting multiple omic data. Trans-omics connects multiple omic layers with the support from prior knowledge of molecular networks such as publicly-available databases for reconstruction of biochemical networks and characterizes the biochemical reactions in the reconstructed network. In this review, we introduce the concept of trans-omics analysis and the ideas for integration of newly developed proteomics data into trans-omics network.