Large-scale Disease Proteomics by Aptamer Technology

Abstract

According to the resent progress on the mass spectrometric technologies and the other novel approaches for quantitative protein analysis, the large-scale proteome researches with disease related human specimens have increased. In this report, affinity proteomics are focused on, which could analyze thousands of proteins in blood at the same time. As the technical feature, thousands of artificial DNA aptamers are prepared, then bound to proteins in the blood. The signals on the microarray of each aptamer reflects each target protein amounts. In addition to the technical points, the novel trends and new findings found in more than 200 papers, which might contribute to the future of the proteome research field and social implementation, are also described as our review report.