SERUM INTERLEUKIN-12 LEVELS AND SPLENIC HELPER T CELL SUBPOPULATION IN BABESIA RODHAINI INOCULATED MICE PREIMMUNIZED  WITH BABESIA MICROTI.

RIE HASHIGUCHI-KATO; PHAM NGOC THI; TAKASHI OHMORI; SATOSHI TAMAHARA; MIZUKI  TOMIHARI; TERUMASA SHIMADA; NAOAKI MATSUKI; KENICHIRO ONO

doi:10.32268/jprotozoolres.14.3-4_43

SERUM INTERLEUKIN-12 LEVELS AND SPLENIC HELPER T CELL SUBPOPULATION IN BABESIA RODHAINI INOCULATED MICE PREIMMUNIZED WITH BABESIA MICROTI.

RIE HASHIGUCHI-KATO, PHAM NGOC THI, TAKASHI OHMORI, SATOSHI TAMAHARA, MIZUKI TOMIHARI, TERUMASA SHIMADA, NAOAKI MATSUKI, KENICHIRO ONO

著者情報

RIE HASHIGUCHI-KATO
Department of Veterinary Clinical Pathobiology, Graduate School of Agricultural and Life Sciences, The University of Tokyo, 1-1-1 Yayoi, Bunkyo-ku, Tokyo 113-8657, Japan
PHAM NGOC THI
Department of Veterinary Clinical Pathobiology, Graduate School of Agricultural and Life Sciences, The University of Tokyo, 1-1-1 Yayoi, Bunkyo-ku, Tokyo 113-8657, Japan
TAKASHI OHMORI
Department of Veterinary Clinical Pathobiology, Graduate School of Agricultural and Life Sciences, The University of Tokyo, 1-1-1 Yayoi, Bunkyo-ku, Tokyo 113-8657, Japan
SATOSHI TAMAHARA
Department of Veterinary Clinical Pathobiology, Graduate School of Agricultural and Life Sciences, The University of Tokyo, 1-1-1 Yayoi, Bunkyo-ku, Tokyo 113-8657, Japan
MIZUKI TOMIHARI
Department of Veterinary Clinical Pathobiology, Graduate School of Agricultural and Life Sciences, The University of Tokyo, 1-1-1 Yayoi, Bunkyo-ku, Tokyo 113-8657, Japan
TERUMASA SHIMADA
Department of Veterinary Clinical Pathobiology, Graduate School of Agricultural and Life Sciences, The University of Tokyo, 1-1-1 Yayoi, Bunkyo-ku, Tokyo 113-8657, Japan
NAOAKI MATSUKI
Department of Veterinary Clinical Pathobiology, Graduate School of Agricultural and Life Sciences, The University of Tokyo, 1-1-1 Yayoi, Bunkyo-ku, Tokyo 113-8657, Japan
KENICHIRO ONO 責任著者
Department of Veterinary Clinical Pathobiology, Graduate School of Agricultural and Life Sciences, The University of Tokyo, 1-1-1 Yayoi, Bunkyo-ku, Tokyo 113-8657, Japan

ジャーナルフリー

2004 年 14 巻 3-4 号 p. 43-49

DOI https://doi.org/10.32268/jprotozoolres.14.3-4_43

詳細

抄録

Changes of serum interleukin-12 (IL-12) level and splenic helper T cell (Th cell) subpopulation were examined in the early phase of inoculation with Babesia rodhaini in mice preimmunized with B. microti. Only slight increase of the percentage in parasitized red blood cell was observed in B. rodhaini inoculated preimmunized mice. Serum IL-12 level significantly increased from 6 hr with a peak at 12 hr after the inoculation. In addition, the mice showed a differentiation of helper T cell type 1 (Th 1 cell) and the suppression of helper T cell type 2 in splenic Th cells on day 3 after the inoculation. These results suggested that IL-12 produced in the early phase of infection induced the differentiation of Th 1 cell, by which cellular protective immunity enhanced against Babesia rodhaini infection in preimmunized mice.

責任著者(Corresponding author)

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