Kinetic Studies on Disappearance Pattern of Sulfaquinoxaline from the Organs and Eggs of Chickens

Abstract

Kinetic studies of the residue of sulfaquinoxaline (SQ) in the organs of broilers and laying hens and in the eggs after withdrawal of the drug from either feed or drinking water revealed that the organs could be grouped into 3, based on the disappearance pattern of SQ.
The pattern from the edible organs and the blood, except the kidney, fat and skin, could be explained assuming a two-compartment model, in which a part of the drug administered was stored in a certain place in the body and released slowly after the initial rapid decrease of residural SQ from the organs. The pattern could be described by the following equation,
y=A₁e^-1.5586t +A₂e^-0.4816t
where A₁ and A₂ are nitial concentrations of SQ in the initial and the latter stages, respectively.
The pattern from the kidney could be explained assuming a two-compartment model with a time lag of 0.3 days, and the following equation was found fit to describe the disappearnce pattern from the kidney.
y=A₁e^{-1.1400(t-0.3)}+A₂e^{-0.5350(t-0.3)}
It was suggested that the drug released from the body were sent to the kidney and excreted into the urine. Thus, the kidney was supposed to work as a main excit of the SQ excretion.
The disappearance pattern from the adipose tissue could be well described by the following equation, suggesting that the adipose tissue may not be the storage place for SQ.
y=A₁e^-1.3593t+A₂e^-0.3611t
The disappearance pattern from the whole egg could be described by the following equation, assuming a two-compartment model.
y=0.937e^-3.4431t+0.163e^-0.2261t
Biological half lives from the edible parts except the kidney and adipose tissue in the initial and latter stages were estimated to be 0.45 and 1.44 days, respectively. Those from the whole eggs were estimated to be 0.20 and 3. 07 days, respectively.