Abstract
Hyperuricemia was produced in chickens by artificial infection with nephro-pathogenic infectious bronchitis virus (IBV) and studied. Typical respiratory symptoms were found in all of the chickens after inoculation with the nephropathogenic AM-83 strain of IBV. Sixteen out of 30 chickens died from 4 to 14 days after challenge. The level of uric acid in plasma was very high at the day before death and the values in the majority of chickens was more than about 100mg/dl. The chicken surviving against the IBV challenge had hyperuricemia for a longer time than the dead chickens. A few chickens had hyperuricemia for only one day with very low levels of uric acid.
Chickens in contact with the chickens challenged with AM-83 strain of IBV also died of hyperuricemia, but some of them were resistent to the challenge.
We demonstrated that the hyperuricemia in the chickens infected with IBV was divided into the 4 grades of uncertain, mild, moderate and severe.
