Intracerebroventricularly Administration of Glucagon-Like Peptide-1 Induces Sleep-Like Behavior in the Neonatal Chick

Abstract

It is known that central administration of glucagon-like peptide-1 (GLP-1) (7-36) amide suppresses feeding in rats and chicks, but the mechanisms for this response are still open with special reference to the chick. The present study was done to determine whether GLP-1 induces sleep-like behavior on the neonatal chick. Intracere-broventricular injection of GLP-1 (7-36) amide altered, in a dose-dependent fashion, the behavioral postures of chicks and induced sleep-like behavior compared with the saline control. These results indicate that GLP-1 in the central nervous system may be one of the factors to induce sleeping of the neonatal chick.