The Effects of Gold Thioglucose and Monosodium Glutamate on Growth and Feed Consumption of the Chicken and the Japanese Quail

Abstract

A single intraperitoneal injection of gold thioglucose to the chicken (Gallus domesticus) and the Japanese quail (Cotrunix cotrunix japonica) showed that the LD 50 of the drug was 0.25mg/g body weight for White Leghorn 12-day-old cockerels, 0.1mg/g for the adult male quail and more than 0.1mg/g for the adult female quail.
Neither growth promotion nor increase in feed consumption was observed in the cockerel and the quail which received the LD 50 dose of gold thioglucose, as compared with the cockerel and quail which did not receive the drug. No hyperphagia or obesity was observed in the gold thioglucose-treated-chicken and quail.
No damage to the ventromedial nucleus in hypothalamus was observed in the gold thioglucose-treated-cockerels (Courtesy to the inspection by Dr. Shigeto Kanematsu, Iwate University, Morioka-shi).
Subcutaneous injections of monosodium glutamate at the dosage level of 0.5, 1 and 2mg/g body weight for 10 days to the 3-day-old quail of both sexes did not induce any accerelation of growth or increase in feed consumption as compared with the nontreated control birds.