第94回日本薬理学会年会
セッションID: 94_1-P2-25
会議情報
主催: 第94回日本薬理学会年会
会議名: 第94回日本薬理学会年会
回次: 94
開催地: Sapporo
開催日: 2021/03/08 - 2021/03/10
一般演題（ポスター）
金製剤オーラノフィンの作用機序の考察
キーワード:
antirheumatic agent
詳細
主催: 第94回日本薬理学会年会
会議名: 第94回日本薬理学会年会
回次: 94
開催地: Sapporo
開催日: 2021/03/08 - 2021/03/10
Effect of an antirheumatic gold compound, Auranofin (AF), have been revealed. 1-10 µM of AF inhibited prostaglandin E2 (PGE2) production and nitric oxide (NO) production in macrophages treated with some stimulatory compounds. We found that AF reduced cyclooxygenase (COX)-2 and inducible NO synthase (iNOS) mRNA levels, but not affected their enzyme activities. We then revealed that AF partly inhibited the nuclear-translocation of NF-κB while PGE2 production was almost completely inhibited.
In the review on manuscripts, AF is reported to down-regulate the mRNA levels of SLC47A1, SLC22A1, ATP1A3, ABCG2, SLCO1B1, PIK3CA, and up-regulate the mRNA levels of ABCC3, ABCB1, SLC22A3, ABCC2, SLC31A2, CLTD, CLTB. PGs are known to be transported by 4 transporters, OATP-PG (SLC22A22), SLC21A2 (OATP2A1, SLCO2), SLC21A11 (OATP3A1), and ABCC4, though I could not identify whether AF reduced PGE2 concentration in cellular cultured medium as described above via these transporters by downregulation for export of PGE2.
