抗がん剤の血管外漏出時皮膚傷害に対する罨法の効果に関する基礎的研究

抄録

The management of intravenous therapy is an important task for nurses.Extravasation of drugs is an adverse event of infusion therapy that can occurwith a variety of drugs. The frequency of extravasation of anticancer drugsranges from 0.01% to 6.5% in Europe and the United States and from 0.14% to10.8% in Japan. Although the frequency has decreased over the years,extravasation of anticancer drugs classified as vesicants, can cause necrosisand other skin injuries, thereby increasing the patient's suffering. To treatextravasation, a nurse can administer cold or hot compresses. Cooling is used tolocalize the drug, and heating is used to promote drug absorption. Hotcompresses are recommended for some drugs. However, in an experimental study onlaboratory animals, we found that heating may exacerbate skin disorders.Meanwhile, cooling may reduce (or not exacerbate) skin injuries. Therefore, wecontinue investigating the effective cooling temperature and duration againstskin injury caused by extravasation, with the aim of establishing the safety ofcompresses and providing care that brings comfort to patients. In thispresentation, we would like to share the results of our study on skin injuriescaused by extravasation.