高コレステロール血症は脳動脈瘤破裂に対して保護的に作用する可能性

抄録

[Introduction] subarachnoid hemorrhage (SAH) is a life-threatening stroke and can be mainly caused by a ruptured aneurysm of cerebrovascular blood vessels. One-third of patients could survive with good recovery, one-third will survive with a disability, and one-third will die. It is well known that lowering blood cholesterol levels is mandatory in the prevention of cerebral circulatory disorders. However, the relationship between cholesterol and cerebral aneurysm is still controversial. In this study, we elucidate the above relationship by monitoring aneurysm and SAH in an aneurysm model of LDL receptor/ Apobec 1 double knock out (LA^-/-) mice and that of control mice.

[Method] Hashimoto model of animal cerebral aneurysms was performed. 

Briefly, the left kidney was excised one week before the experiment. Elastase was administered to the subarachnoid space to damage the cerebral artery and sustained-release deoxycorticosterone was placed subcutaneously. 

[Results] 1)The rupture rate of cerebral aneurysms was significantly lower in the LA ^-/- group than in the control group. 2) The collagen layer of the cerebral vessels was sturdier in LA^-/- mice than control mice at one week after the induced aneurysm model. 3) However there is no difference in cerebral vessels including the collagen layer between LA-/- group and the control group in the intact condition.

[Conclusion] In this study, we identified the relationship between cholesterol level and subarachnoid hemorrhage. It will be guessed the transformation of the cerebral vessels had occurred after the aneurysm induction.