主催: 公益社団法人日本薬理学会
会議名: 第96回日本薬理学会年会
回次: 96
開催地: 横浜
開催日: 2022/11/30 - 2022/12/03
Non-tuberculous mycobacterial lung disease (NTM lung disease) is the infection which is caused by mycobacteria, such as Mycobacterium avium (M. avium), M. intracellulare, M. kansasii. The prognosis of NTM lung disease is relative benign than that of TB, but in some cases NTM lung disease is highly resistant to chemotherapy. The incident rate of NTM lung disease is increased and it is estimated that the number of NTM patients exceeds the number of tuberculosis (TB) patients. Here, we investigated the antimicrobial activity of ginseng saponins from red ginseng (Red Ginseng Extract; RGE) against NTM.
We examined whether RGE had antimicrobial activity against M. avium MAH104 strain. RGE inhibited the growth of M. avium at more than 2.0 mg/mL. To elucidate antimycobacterial mechanism of RGE, we established a resistant strain to RGE. RGE-resistant strain grew slower than wild strain. In acid-fast staining, cell wall staining tended to be attenuated in RGE-resistant strain than that in wild type. Protein expression in cell wall fraction from RGE-resistant strain showed some differences from that from wild type.
These results suggest that RGE has the antimicrobial activity against M. avium in vitro. The mechanism of the antimicrobial activity is assumed to be through its effect on the cell wall synthesis.
