Host: The Japanese Pharmacological Society
Name : The 96th Annual Meeting of the Japanese Pharmacological Society
Number : 96
Location : [in Japanese]
Date : November 30, 2022 - December 03, 2022
Multiple stress-related psychiatric disorders exhibit emotional and behavioral disorders, and it is crucial to understand the specific machinery governing these behaviors at the subnuclear level in critical brain regions, such as the amygdala. Within the amygdala, the basolateral amygdala (BLA)-the central nucleus of the amygdala (CeA) circuit is known to mediate fear and anxiety responses. The bed nucleus of the stria terminalis (BNST) is also included in the central extended amygdala together with the CeA, comprising a functional-anatomical macrosystem. Both regions have complex subnuclear organizations. We recently discovered the differential engagement of distinct subnuclei of the central extended amygdala, critical for regulating fear- and anxiety-related behaviors in mice. In this symposium, I will introduce our recent studies and describe how we can dissect the function and molecular constituents of distinct subnuclei in the amygdala. Additionally, I will discuss how the technologies introduced in this symposium have the potential to be used in research on emotional regulation by the brain.
