Host: The Japanese Pharmacological Society
Name : The 97th Annual Meeting of the Japanese Pharmacological Society
Number : 97
Location : [in Japanese]
Date : December 14, 2023 - December 16, 2023
Aging has been progressing rapidly worldwide. Therefore, it is important to investigate age-related differences in disease pathogenesis to develop age-appropriate treatment plan and drug regimen. In this study, we investigated age-related changes in immune function and pathogenesis in a mouse model of asthma. We compared the quantitative and functional changes of various immune cells in untreated or asthma-induced mice between 10-weeks-old (normal group) and 80-weeks-old (aging group) C57BL/6N mice. A mouse model of asthma was generated by repetitive intranasal administration of Dermatophagoides farina. In untreated mice, naive CD4 and CD8 T cells were significantly decreased in the aging group compared with the normal group, whereas effector CD4 and CD8 T cells and regulatory T cells were significantly increased in the aging group compared with the normal group. In a mouse model of asthma, the pathogenesis of asthma was significantly attenuated compared with the normal group based on the result of percutaneous arterial oxygen saturation (SpO2). In addition, the aging group showed a significant decrease in type 2 innate lymphocytes and eosinophil counts. Our findings indicate that significant downregulation of immune function in the aging group attenuated the pathogenesis of asthma.
