Host: The Japanese Pharmacological Society
Name : The 97th Annual Meeting of the Japanese Pharmacological Society
Number : 97
Location : [in Japanese]
Date : December 14, 2023 - December 16, 2023
The nucleus is surrounded by nuclear envelope, a double membrane and about two or three thousand of nuclear pores per one nucleus exist in the nuclear envelope. The nuclear pore complex is a huge structure and consists of about 30 different proteins. A short fiber-like structure extends into the cytoplasm, while a basket-like structure extends into the nucleoplasm. A variety of molecules, such as proteins and RNAs, are transported through the nuclear pores in both directions. The nuclear localization signal (NLS)-containing protein is recognized by importin a in the cytoplasm. Importin b binds to importin a to form a heterotrimeric complex. The trimeric complex translocates through the nuclear pore complex. After translocation of the complex through the nuclear pores, nuclear small GTPase Ran-GTP binds to importin b to trigger the dissociation of the complex. The NLS-substrates become free in the nucleoplasm. Then, importin a and importin b form distinct export complexes in the nucleus together with RanGTP and are recycled back to the cytoplasm by separate pathways. Then importin a and importin b are re-used for next rounds of transport. It has been recently elucidated that the nucleocytoplasmic transport machineries are involved in a variety of cell functions.
