Host: The Japanese Pharmacological Society, The Japanese Society of Clinical Pharmacology
Name : WCP2018 (18th World Congress of Basic and Clinical Pharmacology)
Location : Kyoto
Date : July 01, 2018 - July 06, 2018
Introduction: NMR-Pipetector (PT) is a device to reduce corrosion in water pipe converting Fe(III) to Fe(II) by the electromagnetic power. NMR-Pipetector has been designed to completely eliminate internal corrosion and single cell bacteria from all hot, cold and chilled water pipework systems. It is widely used upon the world, however limited influence has been observed. We previously demonstrated that PT reduced human oxidative stress in a brief exposure (10 minutes) to finger (WCP 2010). In this study, we showed the effect of PT on brain wave (BW) and blood pressure (BP).
Methods: Wrist-type PT (equivalent to 30DS unit) was used. BP of volunteers (n=19) were monitored for 24 hours using Ambulatory BP Monitors TM-2430 (A&D) after obtaining their informed consent. Control BP (CN) without PT were measured every 60 minutes for 24 hours at the initial day. At the second day, BP with magnet dummy device (MD) were measured in the same condition. At the last day, BP with wrist-type PT were measured. The donors had not been informed of order of device during the experiment. BW and pulse rate were monitored using TSDN121 BW amplifier (ATR-Promotions).
Results: Mean of BP with PT, MD and CN (n=12) showed respectively 87.8±3.9 mmHg, 93.3±6.3 mmHg, and 91.1±5.1 mmHg. Significant suppression of 3.3 mmHg BP (p<0.006) was observed by PT-treatment, but no significant change was observed by MD-treatment. PT significantly suppressed not only systolic BP by 4.9 mmHg (p<0.002), but also diastolic BP by 2 mmHg (p<0.03). The most effectively suppressed period of PT was between 10 am and 17 pm within a day (reduction of mean BP: 4.7 mmHg (p<0.0006), systolic BP: 5.7 mmHg (p<0.003), diastolic BP: 4.2 mmHg (p<0.014)). During the daytime, pulse rate was also suppressed by 5 bpm (p<0.006), indicating that RR-interval has been prolonged significantly. PT- treatment reduced oxygen consumption from 8.9±0.6 unit to 8.3±0.6 unit. BW α/β ratio was significantly increased after PT-treatment. Conclusion: Wrist-type PT can be a new device to induce relaxation and to care hypertension-related disease.