CORRELATION BETWEEN HOMOCYSTEINE AND PYRIDOXINE SERUM LEVELS ON ACUTE MYOCARDIAL INFARCTION PATIENTS

Abstract

BACKGROUND: Cardiovascular disease is one of the leading cause of highest mortality rate worldwide. Acute myocardial infarction (AMI) is one of the five major manifestations of coronary heart disease which has the highest mortality rate in Indonesia. Hyperhomocysteinemia is one of the risk factors for the occurrence of AMI. The metabolism of homocysteine is influenced by pyridoxine. Pyridoxine plays role in the transsulfuration of homocysteine with cystationin-beta-synthetase and cystationin-gamma-liases that catalyze the process. This study aims to determine the association of homocysteine with pyridoxine serum levels in AMI patients.

METHODS: Cross sectional design study with 25 samples of AMI patients are selected randomly. The research was conducted from August to November 2016 in Biomedical laboratory of Andalas University. Homocysteine and pyridoxine levels were measured by ELISA method. Data is analyzed by Pearson correlation test.

RESULT: The mean result of examination of homocysteine level was 23.17 (9.2) nmol/ mL, pyridoxine level 128.44 (34.02) pmol/ L. Statistic analysis test found that there is a significant relationship of levels of homocysteine with pyridoxin (r = -0.530 p = 0.006).

CONCLUSION: There is a significant relationship of homocysteine levels with pyridoxine serum levels on patients with acute myocardial infarction.