The role of NSAIDs in the prevention of colorectal cancer

抄録

Background:

The colorectal neoplasm is considered as the third most common cause of cancer-related death in the world and its incidence has continually increased mainly in industrialized countries. Identifying effective cancer prevention strategies to inhibit the growth and progression of the colorectal neoplasm is an essential step to reduce the incidence and mortality of this malignancy.

Methods:

Our work evaluate various epidemiological and experimental data during the five last years and study the molecular mechanisms involved in the chemoprevention of the colorectal neoplasm with the following nonsteroidal anti-inflammatory drugss: aspirin, sulindac, indométhacin,diclofenac, ibuprofen, coxibs and mesalazin.

Results:

Mesalazin presents the best alternative with its efficacy and safety.

Conclusion:

These substances present an important chemopreventive role with concerns about the safety and the efficacy of those substances under some circumstances. More data is required in order to deeply understand the efficacy of NSAIDs as a chemopreventive agent against the colorectal neoplasm.