主催: The Japanese Pharmacological Society, The Japanese Society of Clinical Pharmacology
会議名: WCP2018 (18th World Congress of Basic and Clinical Pharmacology)
開催地: Kyoto
開催日: 2018/07/01 - 2018/07/06
Introduction: Neurological diseases have a profound impact on quality of life. We investigated the risk of suicide attempt in ten neurological diseases.
Methods: Case-control study. Cases were identified from the Danish Poison Information Centre database in the period 2006 to 2013. The prevalence of ten neurological diagnoses was compared with the prevalence in a randomly sampled age and gender matched control group.
Results: We identified 8,974 cases of suicidal attempt and 89,740 controls. We found an association between suicide attempt in nine of ten neurological diseases and disease groups, including stroke (odds ratio (OR) 3.1 [95% confidence interval (CI) 2.8-3.6]), Huntington's disease (OR 8.8 [95% CI 3.2-24.1]), amyotrophic lateral sclerosis (OR 5.0 [95% CI 1.7-14.6]), Parkinson's disease (OR 2.9 [95% CI 1.8-4.6]), Alzheimer's disease and other degenerative diseases (OR 4.8 [95% CI 3.1-7.5]), multiple sclerosis (OR 1.5 [95% CI 1.1-2.1]), epilepsy (OR 4.5 [95% CI 4.1-5.0]), hereditary and idiopathic neuropathy (OR 2.2 [95% CI 1.1-4.3]) and myasthenia gravis (OR 4.3 [95% CI 2.0-9.4]).
Conclusion: Nine out of ten chronic neurological diseases were associated with an increased risk of suicide attempt. These data must be considered for clinicians treating this vulnerable group of patients.
