主催: The Japanese Pharmacological Society, The Japanese Society of Clinical Pharmacology
会議名: WCP2018 (18th World Congress of Basic and Clinical Pharmacology)
開催地: Kyoto
開催日: 2018/07/01 - 2018/07/06
Benzodiazepines are drugs widely used in the treatment of certain emotional disorders, while it has been reported in several publications their undesirable effects. Among the side effects of benzodiazepines, the amnesic effect.
The present study examines the impact of diazepam at a dose of 1mg/kg on cognition in Wistar rats on period of 3 month using the object reconnaissance test, while the results showed a significant decrease in the percentage reconnaissance of the new object for the treated group during the 12-week period compared to the control group.
At this stage of our experiment, we can estimate that the initial objective, namely that of the set-up if there is an association between the administration of benzodiazepines and the cognitive decline in an animal model. We hope that future conditions will allow us to engage in a research process with the aim of highlighting the mechanisms that can induce cognitive decline and Alzheimer's disease.
We conclude that chronic treatment of benzodiazepines is one of the leading causes of cognitive decline. Further study will be conducted in the same direction to determine the mechanism that induces this undesirable effects.
