主催: The Japanese Pharmacological Society, The Japanese Society of Clinical Pharmacology
会議名: WCP2018 (18th World Congress of Basic and Clinical Pharmacology)
開催地: Kyoto
開催日: 2018/07/01 - 2018/07/06
Background: Nowadays many medicinal properties of plants have been discovered from experience accumulated from a long history of their use. The information gathered from folk beliefs can be further analyzed and initiate new ideas for potential usage of plants in the modern evidence-based medicine. Over 1900 beliefs containing information about medicinal plant usage in Latvian-populated territory are found in folklore materials. In total, 216 genera belonging to 81 families were mentioned. Bird cherry Padus avium Mill. is among top 10 the most popular plants.
Methods: The materials described by Smits et all available at the National Library of Latvia were analysed. P. avium was mentioned in 45 folk beliefs. The flowers and fruits of bird cherry were harvested in countryside of Latvia during full flowering stage in June and mature fruit stage in August, 2017. A part of the material used was fresh and the other one was air dried. Diethyl ether was used as an extraction solvent. Chromatographic and mass spectroscopic (GC-MS, LC-MS) methods were performed to identify compounds in P. avium flowers and fruits.
Results: The analysis of folk materials provided evidence that different parts of bird cherry including bark, fruits, flowers and leaves traditionally have been used as teas, tinctures and as fresh material for topical application to treat headache, toothache, pain in ears, neck and stomach, diarrhoea, cough, erysipelas, bruises and swelling. Analysis by GC-MS found about 100 compounds in P. avium flower extracts and 22 compounds were present in more than 1% relative concentration. More than 10 phenolic components (flavonoids) and their glycosides were found in flower extracts by LC-MS analysis. The most significant constituents found in flowers were chlorogenic acid, hyperoside and isoquercetin. P. avium fruits contained two anthocyanins: cyanidin-3-rutinoside and cyanidin-3-glucoside; other flavonoids, such as quercetin and epicatechin; and phenolic acids: chlorogenic acid and its isomer 4-O-caffeoylquinic acid.
Conclusions: The flowers and fruits of bird cherry Padus avium Mill. are rich source of bioactive compounds (anthocyanins, flavonoids, phenolic acids) and extracts will be further studied to obtain evidence for activities described in folk believes.
