MANGIFERIN A NATURALLY OCCURRING GLUCOSYLXANTHONE OBTAINED BY SPRAY DRY WITH INCREASED SOLUBILITY USING HPMC, AS AN ACTIVE PHARMACEUTICAL INGREDIENT FOR NEW PHARMACOTHERAPEUTIC APPLICATIONS

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Mangiferin is a natural glucosylxanthone widely distributed in higher plants such as Mangifera indica L. and Anemarrhena asphodeloides Bung showing antidiabetic, antitumor, antiviral, antioxidant, immunomodulatory and anti-inflammatory activities. The solubility of this compound in water is small, then; we prove to increase the solubility of Mangiferin in water using Spray Dried with hydroxypropyl methylcellulose (HPMC). Previously, the solubility in several solvents was determinated. To prepare the solutions of Mangiferin-HPMC was used two different HPMC: E10M and K100M. The solutions were prepared in different proportions of Mangiferin/HPMC using methanol/ethanol (50/50) as solvent. After that, they were stirred for 24 hours and dried by Spray Dry at 70 and 500C inlet and outlet temperature, respectively. The powder was characterized by size particle, content of mangiferin, DSC and dissolution test in water. The obtained results demonstrate that HPMC K100M was better than HPMC E10M and the better proportion was 1 g of Mangiferin by 1 g of HPMC K100M. All samples show higher solubility than mangiferin in dissolution test, then; we can conclude that the used method permitted to increase the solubility of mangiferin as active ingredient for new pharmacological applications.