抄録
Caesalpinia bahamensis Lam is a medicinal plant used by Cuban population to treat renal and hepatic problems; peptic ulcer and diabetes mellitus. The diuretic effect of aqueous extract in rodents has been evaluated with similar results to Furosemide. For other side, 74 compounds have been identified by Gas Chromatography/Mass Spectrometry; which were related to fatty acids, terpenoids and phytosterols structures. In general, the scientific information about this plant is few; then; we show the quality parameters of the drug, the characterization of the hydroalcoholic and aqueous extracts, the isolation and identification of the main compounds of the drug and its biological properties. Also, the oral acute toxicity was evaluated. The quality parameters of the drug were determinated following the methods described in Chinese Pharmacopeia and the characterization of extracts were realized by Miranda and Cuellar 2000. The antioxidant effect was evaluated by DPPH and FRAPS methods; the diuretic effect was determinated by individual metabolic cages in Wistar rats and the antilithiatic effect was evaluated by in vitro and in vivo techniques. Finally, to isolate and identify the compounds of the drug were used chromatographic and spectroscopic methods. In general, the plant showed antioxidant, diuretic and antilithiatic effect. For other side, the drug didn't show oral acute toxicity at 2000 mg/Kg. Finally, the isolated compounds were related with structures of fatty acids, terpenoids, phytosterols, flavonoids and phenolic compounds, which should be responsible of its biological effects. These results that are shown in this investigation constitute the preliminary bases for the future development of new herbal drugs of therapeutic interest.
Acknowledged: This research was possible with the special financial contribution of two VLIR UOS projects Nr. ZEIN2016PR418 from Flemish Belgium VLIR collaboration program and the Project of Institute of Food and Pharmacy, Havana University.
