一般論文
市販乳糖の物理的性質と錠剤特性
1997 年 57 巻 1 号 p. 1-7
詳細
1997 年 57 巻 1 号 p. 1-7
The relationship between the physical properties of various kinds of lactose on the market and characteristics of their tablets was investigated. For powdered and granular lactoses, the crystallinity, specific surface area, mean particle diameter and water content were determined. The hardness and thickness of tablets prepared with the powdered and granular lactoses were evaluated. For the powdered lactoses, the crystallinity and water content were nearly equal among manufacturers. For the granular lactoses, the crystallinity, specific surface area and water content varied among manufacturers. When the granular lactoses of lower crystallinity than the powdered lactoses were stored at high relative humidity, the crystallinity and water content increased due to crystallization to α-monohydrate. The tablet hardness prepared with the powdered lactoses increased with the increase in specific surface area. In the case of granular lactoses, the tablet hardness decreased linearly with the increase in the crystallinity of the lactose.
