1997 年 57 巻 1 号 p. 16-24
Various types of scored tablets have been designed recently to adjust doses to match the conditions of individual patients. However, many types of scored tablets are not well designed for dividing. Therefore, it is difficult to divide these tablets evenly, and fairly large weight variation occurs following the division. We analyzed various types of scored tablets by the ANOVA method. As a result, it is believed that factors which affect the divisibility are the hardness of tablet, the depth of score, the angle of score and the thickness of the tablet at the scored location. Based on these analyses, tablets with newly designed score shapes were manufactured. We found that tablets having a score three times wider and two times deeper than conventionally scored tablets, and also having small R shapes at each edge of the score are divided easily by hand into two equal halves with a small weight variation. These tablets are resistant to stress during various processes such as inspection, packaging and transportation. The tablets mentioned above were manufactured using a popular rotary-type tableting machine, and no problems attributed to tablet shape were observed during production.