1997 年 57 巻 1 号 p. 33-39
Oral mucosal bioadhesive films of diltiazem were prepared from the mixture of the drugs chitosan and sodium alginate using glycerol as the plasticizer. In vitro adhesion properties of the films were observed to be comparable to commercial formulation. In vitro release of diltiazem from the bioadhesive films was rapid, with almost 100% release within 2-3 h. When the films were administered to a sublingual site on rabbits, diltiazem from the films was rapidly absorbed from the oral mucosa into systemic blood. The bioavailability of diltiazem was ca. 60% from films with a 1:3 chitosan: alginate weight ratio when administered sublingually to rabbits as compared to ca. 30% by oral administration. The data suggest that films prepared from chitosan and sodium alginate are potential candidates for intraoral drug delivery.
