ノート
In Vivo Estimation on the Distribution of Anti-Helicobacter pylori Agents to the Gastric Mucosa
2001 年 61 巻 2 号 p. 71-76
詳細
2001 年 61 巻 2 号 p. 71-76
Effective levels of antimicrobial drugs are required for the successful eradication of Helicobacter pylori (H. pylori) from the gastric mucosa. We examined the stabilities of two typical anti-H. pylori drugs, amoxicillin (AMX) and metronidazole (MZ), in artificial gastric juice (pH 1.2 or pH 4.0). We administered the drugs to mice parenterally or orally (po) and investigated the efficacy of their delivery at the gastric mucosa. MZ degraded only slightly in the artificial gastric solutions, while AMX was unstable in acidic conditions. Delivery to the gastric mucosa was scarcely observable in the case of parenteral AMX administration. However, delivery was readily detectable after po delivery of the suspension, although serum concentration was lower than with intraperitoneal injection. MZ was delivered to gastric mucosa after intravenous injection, and the amount increased according to the serum MZ level. The concentration of MZ in the gastric mucosa after po administration was greater than with parenteral administration.
