総説
シクロデキストリンの製剤への新たな利用展開
キーワード:
DM-β-CyD,
γ-CyD,
inclusion complex,
polypseudorotaxane,
multi-functional drug carrier,
liposome,
polymorphism
2007 年 67 巻 2 号 p. 66-79
詳細
2007 年 67 巻 2 号 p. 66-79
Among the natural cyclodextrins (CyDs), bioadaptable γ-cyclodextrin (γ-CyD) is particularly useful in the design of CyD-based pharmaceutical formulations. In addition, the multi-functional characteristics of 2,6-di-O-methyl-β-CyD (DM-β-CyD) is capable of alleviating the undesirable properties of drug molecules through the formation of inclusion complexes. The objective of this contribution is to outline the recent findings on the potential of γ-CyD and DM-β-CyD as advanced drug carriers, focusing on their ability to increase the drug absorption across biological barriers, the ability to control the rate and time profiles of drug release, and the ability to deliver adrug to a targeted site. Moreover, a novel approach for the selective isolation of Ostwald's intermediate of metastable polymorphs occurring during an early stage of crystallization will be discussed by utilizing the complex formed with DM-β-CyD.
