薬剤学
Online ISSN : 2188-3149
Print ISSN : 0372-7629
ISSN-L : 0372-7629
一般論文
新規超高速撹拌混合機を用いた乾式コーティングによる徐放性粒子の調製
永沼 剛西田 渉坂本 宜俊樺澤 一弘今井 健吾湯淺 宏
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2009 年 69 巻 6 号 p. 452-460

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The purpose of this study was to demonstrate that the phenomenon induced by mixing powder components at an ultrahigh speed could be directly applicable to the preparation of drycoated particles with a controlled-release property. In particular, we tried to prepare controlled-release particles that were dry-coated on microcrystalline cellulose particles (CP-203) as a core particle.

The controlled-release coating agents, hydrogenated castor oil (HCO) and polyethylene glycol (PEG), formed a matrix layer with dispersed theophylline (TP) as a model drug on CP-203 by mixing the dry components at an ultrahigh-speed. By this method, single controlled-release particles could be produced. Dissolution of TP from the particles was controllable by regulating the initial mass ratio of CP-203, TP, HCO, and PEG. The new method showed high reproducibility in terms of the particle product characteristics, with no need for pre-mixing of the components.

In conclusion, this study shows that a simple preparation of controlled-release particles has been achieved using a new dry-coating method, without organic solvents or water. The single, coated particles obtained show promise as a basic component for manufacturing multiple-unit type formulations consisting of controlled-release particles.

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© 2009 公益社団法人 日本薬剤学会
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