Journal of Physical Therapy Science
Online ISSN : 2187-5626
Print ISSN : 0915-5287
Original Article
Differences in strength-duration curves of electrical diagnosis by physiotherapists between DJ-1 homozygous knockout and wild-type mice: a randomized controlled pilot trial
Ju-Hyun KimWon-Deok LeeMee-Young KimLim-Kyu LeeByoung-Sun ParkSeung-Min YangJi-Woong NohYong-Sub ShinJeong-Uk LeeTaek-Yong KwakTae-Hyun LeeJaehong ParkBokyung KimJunghwan Kim
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2016 Volume 28 Issue 5 Pages 1595-1598

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Abstract

[Purpose] Strength-duration (SD) curves are used in electrical diagnosis by physiotherapists to confirm muscle degeneration. However, the usefulness of SD curves in comparing muscle degeneration in DJ-1 homozygous knockout (DJ-1−/−) and wild-type mice (DJ-1+/+) is not yet fully understood. The electrical properties of the gastrocnemius muscles of DJ-1−/− and DJ-1+/+ mice were compared in the current study. [Subjects and Methods] The electrode of an electrical stimulator was applied to the gastrocnemius muscle to measure the rheobase until the response of contractive muscle to electrical stimulation became visible in mice. [Results] The rheobase of DJ-1−/− mice showed a significant increase in a time-dependent manner, compared to that of DJ-1+/+ mice. [Conclusion] These results demonstrate that the DJ-1 protein may be implicated in the regulation of neuromuscular activity of gastrocnemius muscles of mice.

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© 2016 by the Society of Physical Therapy Science. Published by IPEC Inc.
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