The Effects of Rehabilitation on the Immune Responses in Patients I: The Effects of Exercise Training on the T-cell Activity in Chronic Hemodialysis Patients

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This paper presents our investigation of the effects of therapeutic exercise on the number of white blood cells and on the T-cell activity, in the peripheral blood of chronic hemodialysis patients. A significant decrease in the number of lymphocytes, and a significant increase in the number of monocytes were observed in peripheral bloods collected from patients before exercise training, as compared with those from healthy persons. No difference in the number of neutrophiles was observed between the patients and healthy persons. The number of monocytes, in the hemodialysis patients, decreased to a normal level after exercise but the number of lymphocytes did not change after 3 weeks exercise. A significant reduction in T-cell activity, determined by the response to PHA, was observed in patients both at pre- and post-exercise. Significantly higher blastogenic responses were found in patients after exercise, when compared with those before exercise, suggesting that the therapeutic exercise was effective at increasing T-cell activity. A higher rate of recovery of T-cell activity was observed in patients with low-responding T-cells. T-cell activity in hemodialysis patients was closely related to their usual daily number of steps, but not to their exercising capacity.