Cellular Localization of Nerve Growth Factor (NGF) and Its Receptors TrkA and p75LNGFR in the Ovary of the Japanese Monkey (Macaca fuscata fuscata)

Keiko SHIMIZU; WanZhu JIN; Chihiro KOJIMA; ZhanQuan SHI; Masahiro KONDO; Mariko ITOH; Gen WATANABE; Kazuyoshi TAYA

doi:10.1262/jrd.48.377

Original Articles

Cellular Localization of Nerve Growth Factor (NGF) and Its Receptors TrkA and p75LNGFR in the Ovary of the Japanese Monkey (Macaca fuscata fuscata)

Keiko SHIMIZU, WanZhu JIN, Chihiro KOJIMA, ZhanQuan SHI, Masahiro KONDO, Mariko ITOH, Gen WATANABE, Kazuyoshi TAYA

Author information

Keiko SHIMIZU
Department of Cellular and Molecular Biology, Primate Research Institute, Kyoto University
WanZhu JIN
Laboratory of Veterinary Physiology, Tokyo University of Agriculture and Technology
Department of Basic Veterinary Sciences, The United Graduate School of Veterinary Sciences, Gifu University
Chihiro KOJIMA
Laboratory of Veterinary Physiology, Tokyo University of Agriculture and Technology
ZhanQuan SHI
Laboratory of Veterinary Physiology, Tokyo University of Agriculture and Technology
Department of Basic Veterinary Sciences, The United Graduate School of Veterinary Sciences, Gifu University
Masahiro KONDO
Department of Basic Veterinary Sciences, The United Graduate School of Veterinary Sciences, Gifu University
Mariko ITOH
Department of Cellular and Molecular Biology, Primate Research Institute, Kyoto University
Gen WATANABE
Laboratory of Veterinary Physiology, Tokyo University of Agriculture and Technology
Department of Basic Veterinary Sciences, The United Graduate School of Veterinary Sciences, Gifu University
Kazuyoshi TAYA
Laboratory of Veterinary Physiology, Tokyo University of Agriculture and Technology
Department of Basic Veterinary Sciences, The United Graduate School of Veterinary Sciences, Gifu University

Keywords: NGF, TrkA, p75LNGFR, Ovary, Japanese monkey

JOURNAL FREE ACCESS

2002 Volume 48 Issue 4 Pages 377-381

DOI https://doi.org/10.1262/jrd.48.377

Details

Abstract

Cellular localization of nerve growth factor (NGF) and its receptors (TrkA, p75LNGFR) in the ovary of the Japanese monkey (Macaca fuscata fuscata) was investigated using immunohistochemistry. Strong positive immunostaining for NGF was confined to granulosa and theca cells of large antral follicles in the ovary. The interstitial cells also showed positive immunostaining for NGF. The intensity of immunostaining for TrkA was stronger in granulosa and interstitial cells than in theca cells. Immunoreactions for p75LNGFR were detectable in granulosa, interstitial and theca cells of the ovary. These results strongly suggest autocrine and paracrine regulation of follicular function by NGF in the ovary of the Japanese monkey.

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