Expression Pattern Implicates a Potential Role for LRF in the Process of Implantation in Uteri and Development of Preimplantation Embryos in Mice

Yanzhou YANG; Yaping JIN; Amanda C MARTYN; Pengfei LIN; Yujie SONG; Fenglei CHEN; Linyong HU; Chenchen CUI; Xiao LI; Qian LI; Ray LU; Aihua WANG

doi:10.1262/jrd.2012-137

This article has now been updated. Please use the final version.

Expression Pattern Implicates a Potential Role for LRF in the Process of Implantation in Uteri and Development of Preimplantation Embryos in Mice

Yanzhou YANG, Yaping JIN, Amanda C MARTYN, Pengfei LIN, Yujie SONG, Fenglei CHEN, Linyong HU, Chenchen CUI, Xiao LI, Qian LI, Ray LU, Aihua WANG

Author information

Yanzhou YANG
Key Open Laboratory of Animal Biotechnology, Ministry of Agriculture, College of Veterinary Medicine, Northwest A&F University, Yangling Shaanxi 712100, P.R. China
Yaping JIN
Key Open Laboratory of Animal Biotechnology, Ministry of Agriculture, College of Veterinary Medicine, Northwest A&F University, Yangling Shaanxi 712100, P.R. China
Amanda C MARTYN
Department of Molecular and Cellular Biology, University of Guelph, Ontario, Canada N1G 2W1
Pengfei LIN
Key Open Laboratory of Animal Biotechnology, Ministry of Agriculture, College of Veterinary Medicine, Northwest A&F University, Yangling Shaanxi 712100, P.R. China
Yujie SONG
Key Open Laboratory of Animal Biotechnology, Ministry of Agriculture, College of Veterinary Medicine, Northwest A&F University, Yangling Shaanxi 712100, P.R. China
Fenglei CHEN
Key Open Laboratory of Animal Biotechnology, Ministry of Agriculture, College of Veterinary Medicine, Northwest A&F University, Yangling Shaanxi 712100, P.R. China
Linyong HU
Key Open Laboratory of Animal Biotechnology, Ministry of Agriculture, College of Veterinary Medicine, Northwest A&F University, Yangling Shaanxi 712100, P.R. China
Chenchen CUI
Key Open Laboratory of Animal Biotechnology, Ministry of Agriculture, College of Veterinary Medicine, Northwest A&F University, Yangling Shaanxi 712100, P.R. China
Xiao LI
Key Open Laboratory of Animal Biotechnology, Ministry of Agriculture, College of Veterinary Medicine, Northwest A&F University, Yangling Shaanxi 712100, P.R. China
Qian LI
Key Open Laboratory of Animal Biotechnology, Ministry of Agriculture, College of Veterinary Medicine, Northwest A&F University, Yangling Shaanxi 712100, P.R. China
Ray LU
Department of Molecular and Cellular Biology, University of Guelph, Ontario, Canada N1G 2W1
Aihua WANG
Key Open Laboratory of Animal Biotechnology, Ministry of Agriculture, College of Veterinary Medicine, Northwest A&F University, Yangling Shaanxi 712100, P.R. China

Keywords: Estradiol, Implantation, Luman recruitment factor LRF/CREBRF, Progesterone, Uteri

JOURNAL FREE ACCESS Advance online publication

Article ID: 2012-137

DOI https://doi.org/10.1262/jrd.2012-137

The final version of this article is now available: Vol. 59 (2013), No. 3 p. 245

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Abstract

Luman/CREB3 recruitment factor (LRF or CREBRF) was identified as a regulator of Luman (or CREB3) that is involved in the unfolded protein response during endoplasmic reticulum stress. Luman is implicated in a multitude of functions ranging from viral infection and immunity to cancer. The biological function of LRF, however, is unknown. In this paper, we report that uteri of pregnant mice and embryos displayed enhanced LRF expression at all stages, and the expressed LRF was found to be localized specifically at implantation sites. On the other hand, uteri of mice induced for delayed implantation or pseudopregnant mice showed low levels of LRF expression, suggesting that LRF mediates uterine receptivity during implantation. Further, expression of LRF was found to be modulated by steroid hormones such as progesterone and estradiol. This study thereby identifies a potential role for LRF in the process of implantation in uteri and development of preimplantation embryos in mice.

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