Evaluation of Radioprotective Effects of Rajgira (Amaranthus paniculatus) Extract in Swiss Albino Mice

Abstract

The radioprotective efficacy of aqueous extract of Rajgira (Amaranthus paniculatus) leaves against whole body gamma radiation was studied in Swiss albino mice. The oral administration of Rajgira extract at 800 mg / kg body weight / day for 15 consecutive days before whole body exposure to radiation was found to be effective with the LD_50/30 values of 6.33 and 8.62 Gy for irradiation alone and Rajgira + irradiation group, respectively, giving a dose reduction factor of 1.36. This effect of Rajgira accompanied the increased endogenous spleen colonies and the spleen weight without any side effect or toxicity, as well as the modulation of the radiation-induced decrease of reduced glutathione and the radiation-induced increase in lipid peroxidation assessed in the liver and the blood.