Journal of Radiation Research
Online ISSN : 1349-9157
Print ISSN : 0449-3060
Regular Papers
The Potential Cardioprotective Effects of Hydrogen in Irradiated Mice
Liren QIANFei CAOJianguo CUIYicun WANGYuecheng HUANGYunhai CHUAILuqian ZAHOHao JIANGJianming CAI
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2010 Volume 51 Issue 6 Pages 741-747

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Abstract

Most ionizing radiation-induced damage is caused by hydroxyl radicals, and the selective reduction of hydroxyl by hydrogen in vitro has been demonstrated previously. Irradiation of the heart can cause chronic cardiac disease. This study was designed to test the hypothesis that hydrogen-rich water (pure water saturated with molecular hydrogen), which is easy to use, induces cardioprotection against ionizing irradiation injury in mice. In this paper, we demonstrate that hydrogen can protect myocardium degeneration from radiation-induced injury, decrease myocardium malondialdehyde (MDA), 8-hydroxydeoxyguanosine (8-OHdG) levels, and increase myocardium endogenous antioxidants in vivo. We suggest that hydrogen has a cardioprotective effect against radiation induced injury.

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© 2010 by Journal of Radiation Research Editorial Committee
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