Current Topics in DNA Double-Strand Break Repair

Junya KOBAYASHI; Kuniyoshi IWABUCHI; Kiyoshi MIYAGAWA; Eiichiro SONODA; Keiji SUZUKI; Minoru TAKATA; Hiroshi TAUCHI

doi:10.1269/jrr.07130

この記事には本公開記事があります。本公開記事を参照してください。
引用する場合も本公開記事を引用してください。

Current Topics in DNA Double-Strand Break Repair

Junya KOBAYASHI, Kuniyoshi IWABUCHI, Kiyoshi MIYAGAWA, Eiichiro SONODA, Keiji SUZUKI, Minoru TAKATA, Hiroshi TAUCHI

著者情報

キーワード: DNA repair, Homologous recombination, Nuclear foci, Non-homologous end joining

ジャーナルフリー早期公開

論文ID: 07130

DOI https://doi.org/10.1269/jrr.07130

この記事には本公開記事があります。

The final version of this article is now available: Vol. 49 (2008) , No. 2 p.93

詳細

抄録

DNA double strand break (DSB) is one of the most critical types of damage which is induced by ionizing radiation. In this review, we summarize current progress in investigations on the function of DSB repair-related proteins. We focused on recent findings in the analysis of the function of proteins such as 53BP1, histone H2AX, Mus81-Eme1, Fanc complex, and UBC13, which are found to be related to homologous recombination repair or to non-homologous end joining. In addition to the function of these proteins in DSB repair, the biological function of nuclear foci formation following DSB induction is discussed.

責任著者(Corresponding author)

J-STAGEへの登録はこちら（無料）