抄録
The photodynamic inactivation of Escherichia coli strain 15T-, B/r and B was studied using acridine orange and methylene blue as sensitizers. The sensitivity was strongly dependent on the growth phase, namely, the cells at the stationary phase were extremely resistant. Parallel to the sensitivity to ultraviolet or X-rays, strain B/r was less sensitive than strain B. There was no recovery of strain 15T- in a liquid medium (M9) after illumination in the presence of acridine orange. When chloramphenicol was added to this medium, the inactivation proceeded further during the incubation. The syntheses of DNA, RNA and protein were greatly inhibited.
