Journal of Radiation Research
Online ISSN : 1349-9157
Print ISSN : 0449-3060
Effects of Potato Kallikrein Inhibitor and S-Methyl-L-Cysteine Sulfoxide on Plasma and Liver Kininogen Levels of X-irradiated Rats and Effectiveness of these Materials as Radioprotectors
久保寺 昭子色田 幹雄赤星 三弥鶴藤 丞
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1973 年 14 巻 2 号 p. 126-135

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The effect of radiation on kininogen (a precursor of physiologically active peptides, kinins) levels in plasma and liver was investigated. Male rats were exposed to 70O R of X-rays. The kininogen level showed 10-fold elevation in four hours after irradiation and then rapidly returned to the normal value. Effects of liver-protecting compounds, such as PKI (Potato Kallikrein Inhibitor) and MET (S-methyl-L-cysteine sulfoxide), on radiation-induced elevation of kininogen levels in plasma and liver were then investigated. The elevation was strongly suppressed when the animals were treated with these compounds. When tested in mice, these compounds were effective in extending survival time after X-irradiation of 700 R.
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