Changes of Adenylate Energy Charge of Hog Blood Lymphocytes, Platelets and Erythrocytes Following Gamma Irradiation

Abstract

The effect of gamma irradiation on free nucleotides content of hog blood erythrocytes, platelets and lymphocytes in the dose range of 0.5-500 krad, 1 h after irradiation, was examined. In the dose range of 0.25-7 krad significant changes of AMP level were found in all 3 types of cells. In the dose of 30-500 krad significant changes of adenine nucleotides were observed only for blood platelets, concerning AMP, ADP and ATP. The values of adenylate energy charge indicate acceleration of ATP generating sequences in the dose range of 0.5-5 krad. It is suggested that changes of energy charge belong to the first indices of radiationinduced damage.