Incorporation of Tritiated Water (HTO) or Organically Bound Tritium (OBT) into Amino Acids of Rat Brain Proteins

抄録

Three generations of rats were long-term exposed to HTO in drinking water at activity of 37.0 kBq/ ml or to food containing OBT at activity of 48.1 kBq/g. The rats consumed tritiated water and tritiated food ad libitum. The parent females P₀ were exposed for 64 days, the F₁ and F₂ generations were lifetime exposed and F₃ generation during whole intrauterine life. It was found that the amount of tritium incorporated into rat brain protein amino acids after administration of tritiated food was higher than after administration of tritiated water and was the highest in rats exposed during their intrauterine life.