抄録
Effect of calcium diethylenetriaminepentaacetate (Ca-DTPA) and macrophage activating substances, lipopolysaccharide (LPS) and zymosan, on 59Fe release from rabbit alveolar macrophages which ingested 59Fe-iron dextran was studied in vitro. The alveolar macrophages harvested by lung lavage, loaded with the 59Fe-iron dextran were cultured in Hanks'' balanced salt solution (HBSS) at 37°C for 8 hrs with or without the agents. With the addition of 10 mM Ca-DTPA, the 59Fe release was increased to about 4-fold of the control level. Effect of LPS or zymosan was not as large as that of Ca-DTPA, but the simultaneous use of LPS or zymosan with Ca-DTPA enhanced the more elevated 59Fe release.
