The Effect of X-Irradiation on 5-Hydroxytryptamine (Serotonin) Contents in the Small Intestines of Experimental Animals
1962 年 3 巻 2 号 p. 104-108
詳細
1962 年 3 巻 2 号 p. 104-108
The influence on 5-Hydroxytryptamine (5-HT) contents of small intestine of X-irradiation (500-2, 000r whole-body) was studied in rats, mice, guinea-pigs and rabbits. In order to examine the relationship between effect on 5--HT contents and intestinal injury by radiation, mean survival time and incidences of diarrhea were also observed in each species following irradiation.
5-HT contents of small intestine were remarkably reduced by exposure. The depressed level of 5-HT continued 48 hrs. There were great differences in normal contents of 5-HT and reduction rate after exposure among these species. It was found that the species which have high 5-HT contents and large reduction rate after exposure were sensitive to radiation.
The radiation sensitivity of intestine seemed to be closely related with its endogenous 5-HT. Its possible relationship was discussed.
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