X-Ray Sensitivity of Fibroblast Cell Strains Derived from Atomic Bomb Survivors with and without Breast Cancer

A Review of Forty-Five Years Study of Hiroshima and Nagasaki Atomic Bomb Survivors II. BIOLOGICAL EFFECTS

Abstract

Fibroblasts were established in vitro from skin biopsies obtained from 55 women and 1 man with or without breast cancer and with or without exposure to radiations from the atomic bomb (A-bomb) explosion in Hiroshima. The radiosensitivity of these cells was evaluated by clonogenic assays after exposure to X rays. Dose-response curves were fitted to a multitarget model, S/S₀ = A[1-(l-e^-D/D₀)^N]. There was no difference in the means or variances of radiosensitivity between exposed and nonexposed groups, or between groups with and without breast cancer.