抄録
Purpose: We analyzed intermediate risk factors in ophthalmologic study of A-bomb survivor. Subjects: The AHS participants who were age 13 or less at the time of the bombs and those who had the previous ophthalmologic examination during 1978-1980. Methods: Slit lamp examination, digital photograph, and classification by the Lens Opacity Classification System. We selected items statistically significant both with radiation dose and cataract from ophthalmologic findings, 23 cataract related questionnaires and 15 clinical laboratory tests. Results: During the period, 873 persons underwent the ophthalmologic examination. Statistical significance in dose response was observed in cortical and posterior subcapsular opacities, but not in nuclear color and nuclear opacity. Inflammation and calcium were found to be significant as intermediate risk factors. Conclusion: Thus, presence of intermediate risk factors in A-bomb survivors strongly suggests a presence of indirect effects in radiation cataractogenesis. [J Radiat Res 44:387 (2003)]
