抄録
We investigated the effect of 10 and 6 tesla (T) static magnetic fields (SMFs) on the expression of proto-oncogenes using western blot hybridization methods. 10 T is the highest magnetic flux density and 6 T has the strongest magnetic field gradient (41.7 T/m) in our SMF exposure system. We used the human promyelocytic HL-60 cells. HL-60 cells were exposed to the SMFs for 1, 2, 4, 8, 24, 36, 48, and 72 hours. The cells exposed to either 6 T or 10 T SMF for periods of 1 - 48 hours did not exhibit remarkable differences in levels of c-MYC and c-FOS expression, as compared to sham-exposed cells. On the contrary, c-JUN protein expression increased in HL-60 cells following exposure to 6 T SMF for 24, 36, 48, and 72 hours. These results suggest that 10 T SMF is unlikely to alter the expression of proto-oncogenes. However, the exposure to strong magnetic field gradient might induce the c-JUN expression. [J Radiat Res 44:418-419 (2003)]
