抄録
INTRODUCTION: Recently, human exposure to an extremely low frequency magnetic field (ELFMF) from various electrical appliances has increased significantly. Thus, the possible health effects of exposure to ELFMF have become a considerable public concern. On the other hand, occurrence of diabetes mellitus has increased progressively in recent years. Insufficient pancreatic islet function is the basis of various forms of diabetes. These two factors motivated us to investigate the effects of exposure to ELFMF on the function of insulin secreting cells. METHODS: We stimulated RIN-m, an islet-derived insulinoma cell line, to secrete insulin under exposure to an ELFMF (60 Hz and 5 mT) or under sham-exposure conditions. RESULTS: In the presence of a depolarizing concentration of potassium (45 mM KCl), exposure to the ELFMF significantly attenuated insulin release from RIN-m cells, compared to sham-exposed cells. The results of flowcytometric analysis indicated that ELFMF exposure prevented cell membrane depolarization. CONCLUSION: In this study, we detected the inhibitory effects of ELFMF on insulin secreting cells.
