抄録
Alpha-tocopherol monoglucoside (TMG) exhibits high antioxidant activity and radioprotective effect in mice irradiated at a dose of 6.6 Gy (Murase et.al, 1997, 1998, Shimanskaya et.al, 2001). We investigated TMG effect on irradiated mice hematopoiesis. CBA mice were whole-body exposed to 5.6 Gy of gamma rays (0,5 Gy per a minute) with using RUM-17 source (copper 0.5 mm + 1.0 mm aluminum, 200 kV, 5 mA). TMG was administered intraperitoneally at a dose of 600 mg/kg immediately after irradiation. Bone marrow and blood cell count were estimated. The largest reduction of myelokaryocytes amount was observed on day 8 after irradiation, and their level was twice higher in TMG treated animals as compared to control. The decrease of lymphocyte percentage in the bone marrow was also two-fold less pronounced in TMG treated mice versus control. TMG administration appeared to clearly intensify hematopoietic recovery starting on day 14 after irradiation as measured by the increase in bone marrow cellularity. The total level of blood leukocytes and their different components count was significantly higher in TMG treated mice in comparison with that of control mice for all days of observation. These data suggest, that TMG administration immediately post mice sublethal dose of gamma irradiation promotes hematopoiesis recovery.
