抄録
DNA double strand break (DSB) is well known as a huge DNA damage introduced by irradiation. On the other hand, in meiosis, scheduled DSBs formation and following recombination intermediates are necessary for appropriate chromosome segregation in the reductional nuclear division. To be efficiently repair ed, the DSBs formation must be strictly regulated, and it is known that in Saccharomycs cerevisiae, at least 10 gene products are required, such as Spo11, Rec102, Rec103, Rec104, Rec114, Mei4, Mer2, Mre11, Rad50 and XRS2, although the precise molecular function has not been figured out. Here, I will present recent data about targeting meiotic DSBs to new sites, using GAL4BD fusion protein.
