抄録
Purpose The aim of this study is to analyze the outcome of radiotherapy as the primary treatment for localized stage IE and IIE diseases.Patients and Methods One hundred and five patients with stage IE and IIE nasal NK/T cell lymphoma were reviewed. There were 83 stage IE and 22 stage IIE. Stage IE was subdivided into limited stage IE confined to the nasal cavity (37 patients), or extensive stage IE with an extension beyond the nasal cavity (46 patients). All except 3 patients received radiotherapy (RT) alone or RT combined with chemotherapy (CT) (CMT). Overall, 31 patients were treated with RT alone, 34 with RT followed by CT, 37 with CT followed by RT and 3 with CT alone.Results Five-year overall survival (OS) and progression-free survival (PFS) for all patients were 71% and 59%, respectively. The 5-year OS and PFS were 78% and 63% for stage IE, and 46% and 40% for stage IIE, respectively. The 5-year OS and PFS were 82% and 80% for limited stage IE versus 75% and 45% for extensive stage IE, respectively. Complete response (CR) was achieved in 91 (87%) patients after RT and/or CT. Initial RT resulted in a superior CR as compared to initial CT, with 54 of 65 (83%) patients achieving CR with initial RT, versus only 8 of 40 (20%) after initial CT. For 102 patients who received RT with or without CT, the outcome of primary treatment with RT alone was compared to that of CMT. Five-year OS and PFS was 66% and 61% for RT alone and 76% and 61%% for CMT.Conclusion RT is a primary therapy in early stage nasal NK/T cell lymphoma.
