Abstract
Purpose:The following was confirmed when we reviewed antitumor effect, blood cell augmentation, an antioxidation effect and subset analysis in T-cell, NK cell activity, TNF -Α, INF-Γ, IL-2, interleukin-12 we paid our attention to macro-glucan, Agaricus, AHCC, antitumor action to have, antioxidation of placebo, adjuvanticity, and to review that mechanism of antitumor effect in organism was immunological enhancement.Methods:Because increase of helper T cell, cytotoxic T cell and suppressor T cell was observed in leukocytes, lymphocytes, increase of a monocytes, and subset of T lymphocyte by Agaricus and macro-glucan administration, by Agaricus, AHCC and macro-glucan administration, immunocompetence activity was found.Results:Immunocompetence activity was found in AHCC from augmentation of NK-cell and cytotoxic T cell and increase of suppressor T cell having been observed.Because Agaricus, AHCC and macro-glucan administration, found antioxidation ability and radical scavenging effect we can expect a radiation protection effect.Conclusion: Tumor growth depression was suggested by Agaricus, AHCC and macro-glucan administration, and, as for the mechanism, it was suggested activity of a macrophage by immunological enhancement and TNF -Α, INF-Γ, IL-2, increase and NK cell of interleukin-12 when active.Immune therapy will attract attention in cancer therapy more and more in future.Therefore, we were able to contribute as fundamental researches of the immune therapy that was specific for carcinoma in cancer therapy.
